Four friends Karla Dodds (Denise Richards), Rebel Carron-Whitman (NeNe Leakes), Joli Symons (Kym Johnson Herjavec) and Sharell Bouvier (Melyssa Ford) head for a much-needed spa retreat weekend away from their husbands, children and busy schedules when suddenly they find themselves downed in a plane crash. With no knowledge of basic survival, the housewives must use their wits and whatever is in their designer bags to try to survive in the rugged wilds. When they realize they are not alone, even frenemies must align to outwit their hunters.