Months after her showdown with Charles Siringo (Cole Hauser), Lizzie Borden (Christina Ricci) has remade herself as a school teacher with a new name in a little town far from Fall River. Seeking peace in anonymity, she's here to be near her sister, Emma (Clea DuVall), whose reaction to ghastly events of the past has put her in an asylum, under the care of an egotistical but renowned doctor. Lizzie's unaware that two famed gunslingers, Bat Masterson (Matthew Le Nevez) and Tom Horn (Chris Bauer), are hunting her, driven to learn the fate of their friend, Siringo. When Lizzie helps a victimized student get justice Lizzie-style, she jeopardizes her cover. Worse, Emma makes a startling choice that leaves Lizzie devastated.