Cast & Characters

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CHARACTER: Dr. Meredith Grey

This Seattle Grace intern may be good at her job, but she has big shoes to fill since her mother was a renound surgeon

Ellen Pompeo

Prior to making her rounds at Seattle Grace, Boston native Ellen Pompeo garnered rave reviews for her role in Brad Silberling's "Moonlight Mile." Soon after, the actress appeared opposite Leonardo DiCaprio in "Catch Me If You Can" and alongside Will Ferrell, Vince Vaughn and Luke Wilson in "Old School.""Her other TV appearances include guest-starring roles in "Friends," "Law & Order" and Lifetime's own "Strong Medicine."

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CHARACTER: Dr. Derek Shepherd

This sexy head of neurosurgery has feelings for Meredith but happens to be married to another doctor.

Patrick Dempsey

Remembered by many as the adorable young dork from such '80s classics as "Can't Buy Me Love" and "Loverboy," Patrick Dempsey has grown up to become a twenty-first-century Hollywood heartthrob. He costarred in "Sweet Home Alabama" opposite Reese Witherspoon and earned an Emmy nomination for his role in the series "Once and Again."

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CHARACTER: Dr. Isobel "Izzie" Stevens

This ex-model turned doctor is out to prove she is confident and capable.

Katherine Heigl

Katherine Heigl started her career as a child model and made her film debut in "That Night," starring Juliette Lewis. Heigl went on to costar with Gérard Depardieu in "My Father the Hero" and in 1999 landed a lead role in the sci-fi series "Roswell."

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CHARACTER: Dr. George O'Malley

Burke is one of the top surgeons out there, and he can't help but fall head over heels for inte

T.R. Knight

Born and raised in Minneapolis, T.R. Knight has performed on Broadway in Michael Frayn's "Noises Off" opposite Peter Gallagher and off-Broadway in "Scattergood." He received a Drama Desk nomination for his work in the latter. Knight was also a series regular in the television show "Charlie Lawrence" with Nathan Lane.

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CHARACTER: Dr. Miranda Bailey

She may act as tough as nails to her interns, but this doc has a heart of gold deep down.

Chandra Wilson

Texas native Chandra Wilson began her acting career at age five with Theater Under the Stars in Houston, where she appeared in more than 10 major musical productions. Wilson was a series regular on the ABC series "Bob Patterson" and has also appeared in "Law & Order: Special Victims Unit," "The Sopranos" and "The Cosby Show."

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CHARACTER: Dr. Alex Karev

He may seem like a softy, but this intern really knows how to step up to the plate.

Justin Chambers

Discovered on a subway in Paris, Justin Chambers began his career as a professional model. After appearing in series such as "Another World" and "New York Undercover," Chambers got his big break in the movie "Liberty Heights" with Adrien Brody. Since then, he's appeared in "The Musketeer" and "The Wedding Planner."

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CHARACTER: Dr. Cristina Yang

His attitude tends to get in the way at times, but this intern is still part of the gang.

Sandra Oh

A familiar face from her 2004 role in the hit flick "Sideways," Sandra Oh's other film credits include "Under the Tuscan Sun" and "The Princess Diaries." The actress has appeared in the TV shows "Arli$$," for which she won a CableAce Award; "Six Feet Under;" and "Judging Amy."

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CHARACTER: Dr. Preston Burke

Don't cross this intern because when it comes to surgeries, she is as hungry as they come.

Isaiah Washington

Isaiah Washington was featured in the Spike Lee films "Crooklyn," "Clockers," "Girl 6" and "Get on the Bus" and was nominated for an NAACP Image Award for his role in "Dancing in September." Washington's television credits include "Ally McBeal," "NYPD Blue," "Soul Food" and "Touched by an Angel."